A benzofuranone type of compound known as 7-hydroxy-3-(1-hydroxyethyl)-5methoxy-3,4-dimethylisobenzofuran-1 (3H)-one (1) and 4,8-dihydroxy-6-methoxy-3,4,5trimethylisochroman-l-one (2) were studied for the molecular modeling using MOPAC.Compound 1 was originally isolated from the fungus Leptosphaeria sp.KTC 727.Initial Nuclear Magnetic Resonance Eng
Unusual Mechanisms of Penile Amputation
Penile amputation is an uncommon and highly morbid injury.Many mechanisms have been reported ranging from self-mutilation and domestic violence to traumatic circumcisions.We present two unusual cases of traumatic smoothing reconstructor penile amputation.An older gentleman endured extensive perineal trauma after being trapped underneath an industri
The Novel Positive Allosteric Modulator of the GABAB Receptor, KK-92A, Suppresses Alcohol Self-Administration and Cue-Induced Reinstatement of Alcohol Seeking in Rats
Positive allosteric modulators (PAMs) of English Longbow the GABAB receptor (GABAB PAMs) are of interest in the addiction field due to their ability to suppress several behaviors motivated by drugs of abuse.KK-92A is a novel GABAB PAM found to attenuate intravenous self-administration of nicotine and reinstatement of nicotine seeking in rats.This p
SARS-CoV-2 quantitative real time PCR and viral loads analysis among asymptomatic and symptomatic patients: an observational study on an outbreak in two nursing facilities in Campania Region (Southern Italy)
Abstract Background In December 2019 an outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 was first observed in Wuhan, China.The virus has spread rapidly throughout the world creating a pandemic scenario.Several risk factors have been identified, such as age, sex, concomitant diseases as well as viral load.A key point is the role of asymp